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Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

12.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Longitudinal Studies01:26

Longitudinal Studies

298
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
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Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Study Designs in Epidemiology01:20

Study Designs in Epidemiology

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Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
561
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

47
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
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Data Collection by Observations01:08

Data Collection by Observations

13.8K
Data collection refers to a systematic way of obtaining, observing, measuring, and analyzing accurate information. Observational studies are one of the most widely used methods of data collection. It involves collecting data by observing the behavior and physical characteristics of a sample without making any modifications to the sample.
An astronomer viewing the motion and brightness of stars in the sky and recording the data is an example of observational data collection. A botanist recording...
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Updated: Nov 1, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Queensland Family Cohort: a study protocol.

Danielle Borg1,2, Kym Rae1,2, Corrine Fiveash3

  • 1Mother and Baby, Mater Medical Research Institute, South Brisbane, Queensland, Australia.

BMJ Open
|June 25, 2021
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Summary

The Queensland Family Cohort (QFC) study tracks 12,500 families for 30 years to understand how family environment impacts child health and development. This longitudinal data informs policy for better public health outcomes.

Keywords:
cell biologyepidemiologyobstetricsphysiology

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Area of Science:

  • Public Health
  • Epidemiology
  • Longitudinal Studies

Background:

  • The perinatal-postnatal family environment significantly influences child health, mental well-being, and educational success.
  • Longitudinal cohort studies are crucial for capturing the long-term effects of societal influences on families.

Purpose of the Study:

  • To establish the Queensland Family Cohort (QFC), a prospective study following 12,500 families for three decades.
  • To identify immediate and future health needs of the Queensland population.
  • To investigate the impact of environmental exposures on family health outcomes.

Main Methods:

  • Prospective, observational, longitudinal design recruiting 12,500 pregnant families in Queensland, Australia.
  • Data collection includes questionnaires, biological samples, and physical measures from parents and children at multiple time points from gestation to postpartum and annually thereafter.
  • Linking environmental exposure data (pollution, household) and government databases for comprehensive analysis.

Main Results:

  • This section is not applicable as the study is ongoing and results are yet to be published.

Conclusions:

  • The Queensland Family Cohort (QFC) will provide critical evidence for informing government policy and practice.
  • Long-term data storage of biological samples will facilitate future biomarker discovery for health and disease.
  • Findings will be disseminated to participants, stakeholders, policymakers, and the scientific community.