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Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver
Dan-Dan Zhu1, Xue-Mei Tan1, Li-Qing Lu2
1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Abstract:
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe cases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the expression of antioxidant proteins, participating in COVID-19-mediated inflammation and liver injury. Here, we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver injury. Additionally, we describe some mechanisms and treatment strategies.
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