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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Related Experiment Video

Updated: Nov 1, 2025

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

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CD58 Immunobiology at a Glance.

Yalu Zhang1, Qiaofei Liu1, Sen Yang1

  • 1Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Frontiers in Immunology
|June 25, 2021
PubMed
Summary
This summary is machine-generated.

The glycoprotein CD58 (also known as lymphocyte-function antigen 3) plays a key role in T/NK cell activation. Soluble CD58 acts as an immunosuppressive factor, making it a potential target for cancer immunotherapy.

Keywords:
CD2CD58LFA-3T cell activationimmune evasionlymphocyte functional antigen-3

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A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice
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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • CD58, or lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor on human tissue cells.
  • CD2, its ligand, is found on T/NK cells, mediating crucial interactions within the immunological synapse.
  • The CD2-CD58 interaction is vital for T/NK cell activation, proliferation, and intercellular signaling.

Purpose of the Study:

  • To provide a comprehensive review of CD58 immunobiology.
  • To highlight the role of CD58 in various immune responses and diseases.
  • To explore the potential of soluble CD58 (sCD58) as an immunotherapeutic target.

Main Methods:

  • Literature review of existing research on CD58 and its interactions.
  • Analysis of the molecular mechanisms underlying CD2-CD58 engagement.
  • Investigation of the role of sCD58 in immune modulation and disease pathogenesis.

Main Results:

  • CD58 is essential for T/NK cell activation, adhesion, and recognition.
  • Soluble CD58 (sCD58) functions as an immunosuppressive factor, impacting T/NK cell responses.
  • Altered sCD58 levels in the tumor microenvironment can lead to T/NK cell immunosuppression.

Conclusions:

  • CD58 is a critical regulator of immune responses, including antiviral and autoimmune processes.
  • The CD2-CD58 pathway is implicated in transplant rejection and tumor immune evasion.
  • sCD58 represents a promising novel target for immunotherapeutic strategies, particularly in oncology.