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Updated: Nov 1, 2025

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

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Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies: A narrative review

Alberto La Valle1, Marco Crocco1, Decimo Silvio Chiarenza1

  • 1Pediatric Clinic and Endocrinology, IRCCS Istituto Giannina Gaslini, Genoa16147, Italy.

World Journal of Diabetes
|June 25, 2021
PubMed

Insights

Endothelial dysfunction (ED) is a key indicator of cardiovascular risk in children and adolescents. Non-invasive techniques like reactive hyperemia-peripheral artery tonometry can detect early ED in pediatric endocrine diseases.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Health
  • Non-invasive Diagnostics

Background:

  • Endothelial dysfunction (ED) involves an imbalance of vasoactive agents, increasing risks for microvascular and macrovascular complications.
  • ED is prevalent in pediatric conditions like type 1 and type 2 diabetes mellitus, obesity, metabolic syndrome, and pituitary dysfunction.
  • Emerging causes of ED include insulin resistance in cancer survivors and transplant recipients.

Purpose of the Study:

  • To review the literature on detecting endothelial dysfunction in children and adolescents with endocrine diseases.
  • To highlight the utility of non-invasive techniques for early ED detection.
  • To focus on the application of EndoPat 2000 in pediatric endocrine populations.

Main Methods:

  • Narrative review of English-language articles.
  • Searched MEDLINE database for studies published between 2005 and 2020.
  • Focused on papers detailing endothelial function assessment using EndoPat 2000.

Main Results:

  • Reactive hyperemia-peripheral artery tonometry (EndoPat 2000) is a non-invasive, reproducible method for assessing peripheral endothelial function.
  • This technique can detect early-stage endothelial dysfunction (ED) before clinical symptoms manifest.
  • The review synthesizes findings on ED detection in pediatric endocrine disease contexts.

Conclusions:

  • Early detection of ED using non-invasive methods like EndoPat 2000 is crucial for identifying at-risk pediatric patients.
  • Timely intervention can prevent the progression to more severe microangiopathic and macroangiopathic impairments.
  • EndoPat 2000 is a valuable tool for assessing endothelial function in children and adolescents with endocrine disorders.

Keywords:
Cancer survivorsEndothelial dysfunctionMetabolic syndromePediatric diabetes mellitusPediatric endocrinopathiesPeripheral artery tonometry

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