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Controllable stereoinversion in DNA-catalyzed olefin cyclopropanation via cofactor modification

Jingya Hao1,2, Wenhui Miao1,2, Shengmei Lu1

  • 1State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Zhongshan Road 457 Dalian 116023 China canli@dicp.ac.cn.

Chemical Science
|June 25, 2021
PubMed
Summary

Researchers engineered G-quadruplex DNA biocatalysts for asymmetric cyclopropanation, achieving high enantioselectivity (+91% ee) and controllable stereoinversion (-72% ee) by modifying the metal-cofactor. This advances DNA catalysis engineering.

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