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Extrapyramidal syndrome and depression induced by flunarizine
A Lugaresi1, P Montagna, R Gallassi
1Institute of Neurology, University of Bologna, Italy.
European Neurology
|January 1, 1988
Abstract:
Apathy, mood depression and extrapyramidal signs consisting of akinesia, amimia, gait apraxia, slight rigidity and tremor were induced in 10 patients by long-term treatment with flunarizine for trivial complaints. These symptoms suggest a mild antidopaminergic activity of flunarizine. Long-term administration of flunarizine should be avoided particularly in the elderly and in patients with extrapyramidal disorders.