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Updated: Nov 1, 2025

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
Published on: May 31, 2024
Posterior cyclodialysis cleft following intravitreal injection
Rachel H Lee1, Aubrey R Tirpack2, Janet L Davis1
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
An unusual complication of intravitreal injections, posterior cyclodialysis clefts, can cause hypotony. Ultrasound biomicroscopy aids in diagnosing these rare posterior clefts when gonioscopy is insufficient.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Ophthalmic Surgery
Background:
- Intravitreal injections are common treatments for various retinal conditions.
- Complications, though rare, require thorough understanding and diagnosis.
Observation:
- A case of hypotony (low intraocular pressure) following an intravitreal injection is presented.
- The hypotony was attributed to a posterior cyclodialysis cleft.
Findings:
- Posterior cyclodialysis clefts are an uncommon cause of hypotony post-intravitreal injection.
- Conventional gonioscopy may fail to visualize posterior clefts.
- Ultrasound biomicroscopy can be a valuable tool for diagnosing posterior cyclodialysis clefts.
Implications:
- This case highlights a rare complication of intravitreal injections.
- Emphasizes the importance of advanced imaging techniques like ultrasound biomicroscopy for accurate diagnosis of hypotony.
- Informs ophthalmologists about potential diagnostic challenges and solutions for post-injection hypotony.
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