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Longitudinal Bone Loss Occurs at the Radius in CKD
Pierre-Emmanuel Cailleaux1,2, Agnes Ostertag1, Marie Metzger3
1Université de Paris, INSERM U1132, Bioscar, Paris, France.
Kidney International Reports
|June 25, 2021
Summary
Chronic kidney disease (CKD) is linked to lower bone mineral density (BMD) and higher parathyroid hormone (PTH). Over 4.3 years, bone loss was observed only at the proximal radius in CKD patients.
Area of Science:
- Nephrology
- Endocrinology
- Orthopedics
Background:
- Chronic kidney disease (CKD) increases the risk of fragility fractures.
- International guidelines suggest bone mineral density (BMD) testing when results influence treatment.
- Understanding bone loss patterns and influencing factors in CKD is crucial.
Purpose of the Study:
- To investigate factors affecting BMD in CKD patients.
- To analyze longitudinal changes in BMD over time.
Main Methods:
- The NephroTest cohort measured BMD at multiple sites (femoral neck, hip, spine, radius).
- Circulating biomarkers and measured glomerular filtration rate (mGFR) were assessed.
- A linear mixed model analyzed longitudinal bone loss and associated factors over 4.3 years in 858 patients.
Main Results:
- Cross-sectional analysis revealed lower BMD at the hip and femoral neck with higher serum parathyroid hormone (PTH) in advanced CKD stages.
- Low BMD was associated with age, gender, smoking, low BMI, and high PTH.
- Longitudinal analysis showed significant bone loss only at the proximal radius over 4.3 years.
Conclusions:
- CKD is associated with reduced BMD and elevated PTH levels.
- Significant longitudinal bone loss in CKD patients was identified specifically at the proximal radius.
Keywords:
bone mineral densitychronic kidney disease–mineral bone disordersfractureosteoporosisparathyroid hormoneMore Related Videos
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