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Dynamic Electroporation Model Evaluation on Rabbit Tissues.

Rodolfo Lauro Weinert1, Marcel Augusto Knabben2, Eduardo Manoel Pereira3

  • 1Applied Electromagnetic Research Group, Department of Electrical Engineering, State University of Santa Catarina - UDESC, Paulo Malschitzki, 200 - Campus Universitário Prof. Avelino Marcante, Zona Industrial Norte, Joinville, SC, CEP - 89219-710, Brazil. rodolfoweinert@gmail.com.

Annals of Biomedical Engineering
|June 25, 2021
PubMed
Summary

This study validates a dynamic model for biological electroporation, showing good agreement between simulations and experiments for electrical current and temperature increase in tissues. The Equivalent Circuit Method accurately captured dielectric dispersion, unlike a commercial Finite Element Method simulator at 50 kHz.

Keywords:
Computational simulationsDielectric dispersionElectroporationRabbit tissues

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Area of Science:

  • Biophysics
  • Computational Biology
  • Biomedical Engineering

Background:

  • Biological electroporation involves creating temporary pores in cell membranes using electric fields.
  • Accurate modeling of electroporation is crucial for understanding its effects on biological tissues.
  • Existing models require validation against experimental data for diverse tissue types.

Purpose of the Study:

  • To validate a dynamic model of biological electroporation in tissues.
  • To compare simulation results with experimental data for electrical current and temperature.
  • To assess the performance of different computational methods, including Equivalent Circuit Method and Finite Element Method.

Main Methods:

  • Computational simulations using Equivalent Circuit Method (ECM) and Finite Element Method (FEM).
  • Inclusion of dielectric dispersion in biological tissues for the ECM.
  • Experimental application of voltage pulses and ramps to rabbit liver, kidney, and heart tissues using needle electrodes.

Main Results:

  • Good agreement between simulated and experimental results, with mean errors below 15%.
  • Simulated results generally fell within the experimental standard deviation.
  • The FEM simulation using commercial software showed significant error (~50%) at 50 kHz due to the exclusion of dielectric dispersion.

Conclusions:

  • The validated dynamic model accurately predicts electrical current and temperature changes during biological electroporation.
  • The Equivalent Circuit Method, incorporating dielectric dispersion, provides reliable simulation results.
  • Limitations of commercial FEM software in modeling electroporation at specific frequencies were identified.