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[An overview on acute kidney injury in COVID-19]

Claudia Altobelli1, Emanuela de Pascale1, Gabriella Di Natale1

  • 1A.O.R.N. Ospedali dei Colli - Monaldi, Cotugno, CTO - P.O. Domenico Cotugno, U.O.C. Nefrologia e Dialisi, Napoli, Italy.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|June 25, 2021
PubMed

Insights

Coronavirus disease 2019 (COVID-19) can cause kidney damage, including acute kidney injury (AKI). Early diagnosis and risk factor assessment are crucial for managing COVID-19 patients with renal complications, though mortality remains high.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • SARS-CoV-2 infection causes COVID-19, frequently associated with renal damage.
  • Patients may exhibit urinary alterations like proteinuria and hematuria, with or without reduced renal function.
  • Acute kidney injury (AKI) is prevalent in critically ill COVID-19 patients, signifying a poor prognosis.

Purpose of the Study:

  • To highlight the occurrence and significance of renal damage in COVID-19 patients.
  • To emphasize the multifactorial pathogenesis and clinical presentations of kidney injury during COVID-19.
  • To underscore the importance of early AKI diagnosis and risk factor assessment in COVID-19 management.

Main Methods:

  • Observational analysis of COVID-19 patient cohorts with renal complications.
  • Review of clinical presentations including urinary findings and renal function.
  • Assessment of AKI as a prognostic factor and impact on mortality.

Main Results:

  • AKI is a common and serious complication in hospitalized COVID-19 patients, particularly in intensive care units.
  • COVID-19 associated AKI is linked to elevated in-hospital mortality rates.
  • Despite therapeutic interventions, mortality in COVID-19 patients with AKI remains a significant concern.

Conclusions:

  • Renal damage, including AKI, is a critical aspect of COVID-19 patient care.
  • Prompt identification of AKI and associated risk factors is essential for nephrological intervention.
  • COVID-19 AKI represents a dynamic and challenging area requiring ongoing research and therapeutic development.

Keywords:
AKICOVID-19CRRTOspedale Domenico Cotugnoextracorporeal purification therapies

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