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Enantiomeric cannabinoids: stereospecificity of psychotropic activity
R Mechoulam1, J J Feigenbaum, N Lander
1Brettler Medical Research Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Experientia
|September 15, 1988
Abstract:
The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).