Related Experiment Video
Updated: Nov 1, 2025
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
6.6K
Neonatal Sepsis-Newer Insights.
Adhisivam Bethou1, Ballambattu Vishnu Bhat2
1Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605006, India. adhisivam1975@yahoo.co.uk.
Indian Journal of Pediatrics
|June 25, 2021
Summary
Neonatal sepsis, a major cause of death in newborns, particularly preterm infants, can be acquired before or after birth. Ongoing efforts focus on diagnostics, prediction scores, and prevention to reduce this global health burden.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Public Health
Background:
- Sepsis is a significant global cause of neonatal mortality and morbidity.
- Preterm neonates in resource-limited settings are particularly vulnerable.
- Infections can be acquired antenatally, perinatally, or postnatally from various sources.
Purpose of the Study:
- To review the epidemiology and risk factors of neonatal sepsis.
- To discuss current and emerging strategies for the prevention and management of neonatal sepsis.
Main Methods:
- Literature review of neonatal sepsis.
- Analysis of contributing factors to sepsis severity.
- Overview of diagnostic and preventive approaches.
Main Results:
- Sepsis acquisition routes include in utero, maternal genital tract, and postnatal environments.
- Severity is influenced by exposure timing, inoculum size, host immunity, and pathogen virulence.
- Various strategies are being developed to combat neonatal sepsis.
Conclusions:
- Neonatal sepsis remains a critical health challenge, especially for preterm infants.
- Multifaceted approaches including advanced diagnostics and preventive measures are crucial.
- Reducing the burden of neonatal sepsis requires continued research and implementation of effective strategies.
