pH and P.E.G.-400 effects on flucloxacillin absorption
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L J Nuñez-Vergara1, I R Lemus, J A Squella
1Laboratory of Pharmacology, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.
General Pharmacology
|January 1, 1988
Abstract:
1. Intestinal clearances of flucloxacillin significantly decrease with the increase of pH, concomitantly with a decrease of the percent absorbed at 60 min. 2. The apparent rate constants for unionized (Ku) and ionized species are 0.173 min-1 and 0.017 min-1 respectively. 3. The addition of P.E.G.-400 at different concentrations significantly enhanced intestinal clearances of flucloxacillin parallel to an increase of net water flux from the lumen of the small intestine.