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Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells

Qi Mu1, Masoud Najafi2

  • 1College of Nursing, Inner Mongolia University for Nationalities, Tongliao 028000, China.

International Immunopharmacology
|June 25, 2021
PubMed

Insights

Resveratrol can modulate the tumor microenvironment (TME) by influencing immune and non-immune cells. This natural compound enhances anti-tumor immunity and reduces cancer cell resistance to therapies.

Area of Science:

  • Oncology
  • Immunology
  • Natural Products

Background:

  • Tumor resistance to therapy is a major challenge in cancer treatment.
  • The tumor microenvironment (TME) comprises diverse immune and non-immune cells crucial for tumor progression and immune suppression.
  • Understanding intercellular communications within the TME is vital for overcoming therapeutic resistance.

Purpose of the Study:

  • To review how resveratrol modulates intercellular communications within the TME.
  • To explore resveratrol's potential in overcoming tumor resistance to therapies.

Main Methods:

  • Literature review on resveratrol's effects on TME components.
  • Analysis of studies investigating resveratrol's immunomodulatory and anti-cancer properties.

Main Results:

  • Resveratrol modulates immune cells (e.g., T lymphocytes, NK cells, macrophages) and non-immune cells (e.g., cancer stem cells, fibroblasts) within the TME.
  • Resveratrol potentiates anti-tumor immunity and attenuates cancer cell and cancer stem cell resistance.

Conclusions:

  • Resveratrol shows promise as a natural agent to enhance cancer therapy efficacy by modulating the TME.
  • Targeting TME interactions with agents like resveratrol could be a strategy to overcome tumor resistance.
Keywords:
Cytotoxic CD8+ T Lymphocytes (CTLs)Natural Killer (NK) CellsResveratrolTumorTumor Microenvironment (TME)

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