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Updated: Nov 1, 2025
09:09
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
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The openCARP simulation environment for cardiac electrophysiology
Gernot Plank1, Axel Loewe2, Aurel Neic3
1Gottfried Schatz Research Center, Division of Biophysics, Medical University of Graz, Graz, Austria.
Computer Methods and Programs in Biomedicine
|June 25, 2021
Summary
openCARP is a new open-source simulation environment for cardiac electrophysiology modeling. It enhances reproducibility and productivity in computational research through automated simulation pipelines and community support.
Area of Science:
- Computational Cardiac Electrophysiology
- Biomedical Simulation Software
Background:
- Cardiac electrophysiology has a long history of computational modeling.
- A lack of community standards for simulation software hinders progress.
Purpose of the Study:
- Introduce openCARP as a potential community standard for cardiac electrophysiology simulation.
- Address the need for a high-usability electrophysiology simulator.
Main Methods:
- Developed the openCARP simulation environment and carputils framework.
- Created automated simulation pipelines for in silico experiments.
- Demonstrated a multi-scale atrial fibrillation simulation workflow.
Main Results:
- openCARP and carputils facilitate the development and sharing of simulation pipelines.
- A growing user community benefits from tailored infrastructure, documentation, and training.
- The software supports multi-scale simulations from cell to body level.
Conclusions:
- openCARP advances computational cardiac electrophysiology by providing accessible, state-of-the-art simulations.
- The combination with carputils offers a tailored solution for the scientific community.
- It promotes increased use, transparency, standardization, and reproducibility in in silico experiments.
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