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Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Venous Thrombosis I: Introduction01:30

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

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Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
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Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Updated: Nov 1, 2025

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
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Patients with Left Ventricular Thrombus Despite Normal Systolic Function.

Christopher Svendsen1, Eric Pauley2, Kristine Falk3

  • 1Jerry M. Wallace School of Osteopathic Medicine, Campbell University, Lillington, NC, United States.

The American Journal of the Medical Sciences
|June 26, 2021
PubMed
Summary
This summary is machine-generated.

Left ventricular (LV) thrombus is rare in patients with normal systolic function. Most patients experience embolic events, often linked to underlying conditions, necessitating long-term anticoagulation.

Keywords:
HypereosinophiliaThromboemboliThrombus

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Area of Science:

  • Cardiology
  • Hematology
  • Internal Medicine

Background:

  • Left ventricular (LV) thrombus formation typically occurs in the context of impaired systolic function.
  • The occurrence of LV thrombus in patients with preserved ejection fraction is exceptionally uncommon.

Observation:

  • This study identified 31 adult cases of LV thrombus with normal LV systolic function.
  • The median age was 43 years, with a male predominance (59%).
  • Embolic complications were the predominant presentation (88%), with a few cases presenting with febrile illness.

Findings:

  • Most LV thrombi in this cohort were associated with underlying conditions such as inflammatory diseases, malignancies, or hypereosinophilia.
  • Common treatments included anticoagulation, surgical excision, or thrombolysis.
  • Recurrence of LV thrombus and embolic events were noted.

Implications:

  • The findings highlight the importance of considering LV thrombus even in patients with normal systolic function, particularly when risk factors are present.
  • Long-term anticoagulation may be crucial for preventing recurrent thrombotic and embolic events in this patient population.
  • Further research into the specific mechanisms and optimal management strategies for LV thrombus in normofunctional ventricles is warranted.