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Composite morphogenesis during embryo development.

Alphy John1, Matteo Rauzi1

  • 1Université Côte d'Azur, CNRS, Inserm, Nice, France.

Seminars in Cell & Developmental Biology
|June 26, 2021
PubMed
Summary

Understanding how embryonic tissues achieve complex shapes is crucial. This study explores how simultaneous tissue folding and extension, vital for gastrulation and neurulation, occur through coordinated cellular mechanisms and gene expression.

Keywords:
Concomitant tissue shape changesConvergence-extensionCoordinated and patterned cell mechanismsFoldingGastrulationGene patterning synergyMulti-tiered cell mechanismsNeurulationTissue mechanics

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Morphogenesis shapes embryonic tissues through gene expression and signaling pathways.
  • Embryonic development involves complex shape changes, including composite morphogenesis.
  • Mechanisms of simple morphogenesis are known, but simultaneous shape changes remain underexplored.

Purpose of the Study:

  • To investigate the mechanisms driving concomitant tissue folding and extension during embryogenesis.
  • To explore how multiple simultaneous shape changes contribute to composite morphogenesis.
  • To highlight the importance of this process for gastrulation and neurulation.

Main Methods:

  • Analysis of pioneering studies on composite morphogenesis.
  • Investigating spatially coordinated cellular mechanisms.
  • Examining the synergy between gene expression patterns.

Main Results:

  • Composite morphogenesis involves multiple, simultaneous shape changes in embryonic tissues.
  • Concomitant tissue folding and extension are critical for gastrulation and neurulation.
  • Spatially coordinated cell behaviors and gene expression synergies drive these complex morphogenetic processes.

Conclusions:

  • Understanding composite morphogenesis is key to comprehending embryonic development.
  • Further research into simultaneous tissue shape changes will elucidate fundamental developmental processes.
  • This work provides insights into the coordinated cellular and genetic mechanisms underlying complex embryonic shaping.