Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prognostic value of PSA bounce after definitive radiotherapy revisited.

International journal of clinical oncology·2021

Same author

Passenger lymphocyte syndrome after ABO-incompatible allogeneic hematopoietic stem cell transplantation; dynamics of ABO allo-antibody and blood type conversion.

Hematology (Amsterdam, Netherlands)·2021

Same author

NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia.

Blood advances·2021

Same author

Characteristics and outcome of acute myeloid leukemia with uncommon retinoic acid receptor-alpha (RARA) fusion variants.

Blood cancer journal·2021

Same author

Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications.

iScience·2021

Same author

How long is long enough to secure disease control after low-dose-rate brachytherapy in combination with other modalities in intermediate-risk, localized prostate cancer?

International journal of clinical oncology·2021

Search research articles

Related Experiment Video

Updated: Nov 1, 2025

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities

Published on: October 27, 2023

Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators.

Mizuki Uenomachi¹, Kenji Shimazoe^2,3, Kenichiro Ogane^4,5

¹Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan. uenomachi-mizuki0710@g.ecc.u-tokyo.ac.jp.

Scientific Reports

|June 26, 2021

Summary

This study introduces a novel double-photon coincidence method to reduce crosstalk in multi-tracer imaging. This technique enhances image quality for nuclear medicine diagnostics and research by minimizing background noise.

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Nov 1, 2025

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities

Published on: October 27, 2023

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Area of Science:

Nuclear medicine
Medical imaging
Biomedical research

Background:

Multi-tracer imaging offers valuable diagnostic and research insights in medical and biological sciences.
Single-photon emission computed tomography (SPECT) is a key nuclear medicine modality with multi-tracer capabilities.
Crosstalk from gamma rays in multi-tracer SPECT degrades image quality, necessitating correction methods like dual- and triple-energy windows.

Purpose of the Study:

To develop and demonstrate a new method for reducing crosstalk in multi-tracer SPECT imaging.
To improve the quality of reconstructed images in simultaneous multi-nuclide imaging.

Main Methods:

Utilizing the coincidence detection of multiple gamma rays emitted by certain nuclides.
Employing GAGG detectors and parallel hole collimators for simultaneous imaging.
Implementing a double-photon coincidence method to differentiate true signals from background crosstalk.

Main Results:

The double-photon coincidence method significantly reduced background noise caused by crosstalk.
Simultaneous imaging of 111In and 177Lu was successfully demonstrated.
The proposed method yielded higher-quality images compared to conventional SPECT imaging techniques.

Conclusions:

The double-photon coincidence method is effective in reducing crosstalk in multi-tracer SPECT imaging.
This technique offers a promising approach for improving image quality in simultaneous multi-nuclide studies.
The method has potential applications in definitive diagnosis and advanced research within medical, biological, and pharmaceutical sciences.