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Related Experiment Video

Updated: Jul 25, 2026

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

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Published on: May 21, 2015

Is SARS-CoV-2 present in the periodontium? A post-mortem study.

Mohammed Adam¹

¹University of Liverpool, Liverpool, UK.

Evidence-Based Dentistry

|June 26, 2021

Summary

SARS-CoV-2 genetic material was found in the periodontal tissues of most deceased COVID-19 patients. This study investigated the virus in periodontal samples from severely ill individuals, noting limited applicability to the general population.

Area of Science:

Oral Pathology
Infectious Diseases
Virology

Background:

COVID-19, caused by SARS-CoV-2, primarily affects the respiratory system.
The presence and impact of SARS-CoV-2 in oral tissues, particularly periodontal tissues, remain an area of investigation.
Understanding viral dissemination in post-mortem tissues can offer insights into disease progression.

Purpose of the Study:

To determine the presence of SARS-CoV-2 in the periodontal tissues of deceased individuals.
To correlate viral detection with histopathological findings in periodontal samples.

Main Methods:

A cross-sectional study involving videoscope-guided post-mortem examination of seven deceased COVID-19 patients.
Periodontal tissue samples (junctional epithelium, oral epithelium, connective tissue) were collected from the maxillary first molar region.

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Samples underwent histopathological analysis (H&E stain) and molecular analysis using real-time reverse transcriptase polymerase chain reaction (rRT-PCR) for the SARS-CoV-2 E gene.

Main Results:

SARS-CoV-2 genetic material was detected in five out of seven (71.4%) periodontal tissue samples.
The mean cycle threshold (Ct) value for detected SARS-CoV-2 was 31.38.
Histopathological analysis revealed nuclear pleomorphism in two cases and vacuolisation in three cases.

Conclusions:

SARS-CoV-2 genetic material is present in a majority of periodontal tissue samples from deceased COVID-19 patients.
The study included a small sample size of severely ill patients with prolonged hospitalisation.
Findings may have limited generalizability to the broader COVID-19 patient population.