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Published on: May 19, 2021
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NT-proANP levels in peripheral and cardiac circulation.
Petra Büttner1, Timm Seewöster2, Danilo Obradovic1
1Department of Cardiology, Heart Center Leipzig At University of Leipzig, Leipzig, Germany.
Summary
N-terminal atrial natriuretic peptide (NT-proANP) levels are elevated in patients with atrial fibrillation (AF) compared to controls. These higher NT-proANP levels, found in both cardiac and peripheral circulation, are associated with AF progression and predict low voltage areas.
Area of Science:
- Cardiology
- Biomarkers
- Electrophysiology
Background:
- Growing evidence links N-terminal atrial natriuretic peptide (NT-proANP) to atrial fibrillation (AF) progression.
- Definitive characterization of NT-proANP levels in peripheral and cardiac circulation in AF patients versus non-AF individuals is needed.
Purpose of the Study:
- To quantify NT-proANP levels in both peripheral and cardiac circulation of AF patients.
- To compare NT-proANP levels between individuals with and without AF.
- To assess the predictive value of NT-proANP for low voltage areas (LVAs) in AF.
Main Methods:
- Blood samples were collected from the femoral vein and left atrium (LA) in 189 AF patients undergoing catheter ablation.
- Control samples were obtained from the cubital vein of 26 non-AF individuals.
- Low voltage areas (LVAs) were identified using high-density mapping during ablation (<0.5 mV).
Main Results:
- AF patients (64 ± 10 years) exhibited significantly higher peripheral and cardiac NT-proANP levels than non-AF controls (58 ± 10 years).
- NT-proANP levels were significantly higher in cardiac circulation compared to peripheral circulation within AF patients (13.0 vs. 11.4 ng/ml).
- Elevated NT-proANP levels (cardiac and peripheral) showed a modest, similar ability to predict LVAs in AF patients.
Conclusions:
- NT-proANP levels are significantly elevated in individuals with AF, with higher concentrations observed in more advanced stages of the condition.
- Both cardiac and peripheral NT-proANP levels serve as comparable predictors of low voltage areas in AF patients.
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