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Updated: Nov 1, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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High Seroconversion Rate Against Severe Acute Respiratory Syndrome Coronavirus 2 in Symptomatic Pediatric

Wenly Ruan1,2, Huyen Nguyen1,2, Allyson Wyatt1,2

  • 1Department of Pediatrics, Baylor College of Medicine.

Journal of Pediatric Gastroenterology and Nutrition
|June 26, 2021
PubMed

Insights

Pediatric inflammatory bowel disease (PIBD) patients with COVID-19 showed high rates of seroconversion against SARS-CoV-2, especially when symptomatic. Further research is needed to understand the implications of this COVID-19 immune response in PIBD.

Area of Science:

  • Immunology
  • Gastroenterology
  • Virology

Background:

  • Pediatric inflammatory bowel disease (PIBD) management involves immunosuppression, potentially impacting immune responses to infections.
  • Understanding coronavirus disease 2019 (COVID-19) in PIBD patients is crucial for clinical care and disease management.

Purpose of the Study:

  • To investigate SARS-CoV-2 seroconversion rates in immunosuppressed PIBD patients.
  • To correlate COVID-19 symptoms and seroconversion in this cohort.

Main Methods:

  • Single-center cohort study of PIBD patients with confirmed SARS-CoV-2 infection.
  • Analysis of clinical course, medications, COVID-19 symptoms, and SARS-CoV-2 immunoglobulin G (IgG) antibody testing.

Main Results:

  • 14 PIBD patients tested positive for SARS-CoV-2; 12 underwent IgG testing.
  • All 7 symptomatic patients seroconverted; 3 of 5 asymptomatic patients seroconverted.
  • No PIBD patients required hospitalization for COVID-19.

Conclusions:

  • High rates of SARS-CoV-2 seroconversion observed in immunosuppressed PIBD patients, particularly those with symptoms.
  • The clinical significance of COVID-19 seroconversion in PIBD warrants further investigation.

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