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Enantioselective Heck-Matsuda Reactions: From Curiosity to a Game-Changing Methodology
Caio C Oliveira1, Carlos Roque Duarte Correia1
1Institute of Chemistry, University of Campinas, Josué de, Castro, 10384-612, São Paulo, Brazil.
Abstract:
The enantioselective palladium-catalyzed Heck arylation of olefins using arenediazonium salts is one of the last features in the evolution of a synthetic method known as the Heck-Matsuda reaction. This personal account highlights the development of the enantioselective Heck-Matsuda reaction in its initial stages, the challenges faced along the way, and the interesting findings that opened new synthetic opportunities, mainly from our laboratory, featuring the Heck-Matsuda reaction as a central player in the synthesis of bioactive and functional molecules.
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