Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A paramagnetic agent causing ochronotic arthropathy.

J F Norfray1, W G Klingler, I A Menon

  • 1MR Center Springfield, Ltd., IL 62701.

Investigative Radiology
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cadherin switch from E- to N-cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail.

The British journal of dermatology·2012
Same author

Drug utilization patterns in pregnant women: a case study at the Mount Hope Women's Hospital in Trinidad, West Indies.

The West Indian medical journal·2011
Same author

Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation.

The Journal of cell biology·2001
Same author

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.

The Journal of biological chemistry·2001
Same author

Polyhydroxyalkanoate accumulation in Burkholderia sp.: a molecular approach to elucidate the genes involved in the formation of two homopolymers consisting of short-chain-length 3-hydroxyalkanoic acids.

Applied microbiology and biotechnology·2000
Same author

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same journal

3D Freehand Ultrasound Imaging of Optic Nerve Sheath.

Investigative radiology·2026
Same journal

Iodinated Contrast Media Hypersensitivity in 115,966 Patients: Risk Factors, Severity Profiles, and the Impact of Iodine Concentration on Reaction Risk.

Investigative radiology·2026
Same journal

Improvement of Lung Nodule Volumetric Accuracy with Photon-counting Computed Tomography Over Energy-integrating Computed Tomography in Low-dose Screening: A Phantom Study.

Investigative radiology·2026
Same journal

Photon-counting CT in Anterior Cervical Discectomy and Fusion: Improved Metal Artifact Reduction and Impact on Bone Fusion Assessment.

Investigative radiology·2026
Same journal

Quantitative Synthetic MRI in Body Imaging: Technical Basis, Current Applications, and Future Directions.

Investigative radiology·2026
Same journal

Nonclinical Safety Assessment of Digadoglucitol, a Novel Magnetic Resonance Imaging Contrast Agent for the Central Nervous System.

Investigative radiology·2026
See all related articles

Melanin, a paramagnetic substance found in ochronosis patients, causes cartilage damage through free radicals. This finding explains cartilage loss in ochronotic arthropathy at an electron level, linking it to oxygen toxicity.

Area of Science:

  • Biochemistry
  • Medical Imaging
  • Rheumatology

Background:

  • Ochronotic arthropathy involves progressive cartilage degeneration.
  • The underlying molecular mechanisms of cartilage loss in ochronosis are not fully understood.

Observation:

  • Magnetic resonance imaging (MRI) detected a paramagnetic substance in the hyaline cartilage of hips and knees in a patient with ochronosis.
  • Chemical analysis identified this paramagnetic agent as melanin.

Findings:

  • Melanin contains free radicals that initiate cytotoxicity, leading to cell damage.
  • The superoxide theory of oxygen toxicity explains cartilage loss in ochronotic arthropathy at the electron level.

Implications:

  • This research provides an electron-level explanation for cartilage degeneration in ochronosis.

Related Experiment Videos

  • Inappropriate oxygen metabolism may also contribute to early cartilage degeneration in hemochromatosis, hemosiderosis, and Wilson's disease.