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Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
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Association between protoporphyrin IX and sarcopenia: a cross sectional study
Chia-Chun Kao1, Zhe-Yu Yang1, Wei-Liang Chen2,3,4
1Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taiwan, Republic of China.
BMC Geriatrics
|June 27, 2021
Summary
This study found a significant association between protoporphyrin IX (PPIX) and sarcopenia in older adults. PPIX may serve as a potential indicator for diagnosing sarcopenia.
Area of Science:
- Gerontology
- Biochemistry
- Mitochondrial Biology
Background:
- Sarcopenia diagnosis focuses on muscle strength, quality, and quantity.
- Mitochondrial dysfunction is a known contributor to sarcopenia.
- The role of mitochondrial intermediates like protoporphyrin IX (PPIX) in sarcopenia is unexplored.
Purpose of the Study:
- To investigate the association between PPIX and sarcopenia.
- To explore PPIX as a potential indicator for sarcopenia.
Main Methods:
- Utilized data from 1172 participants without anemia from the NHANES database (1999-2002).
- Employed multivariable logistic regression to analyze the relationship between PPIX and sarcopenia.
- Performed covariate adjustments in three models for robust analysis.
Main Results:
- A significant association between PPIX and sarcopenia was observed in unadjusted models (OR=3.910, P<0.001).
- This association remained statistically significant after covariate adjustments (OR=2.537, P=0.002).
Conclusions:
- The study demonstrates a statistically significant link between PPIX and sarcopenia.
- PPIX shows potential as a valuable biomarker for sarcopenia detection.
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