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A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
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[Thrombin generation assay in autoimmune disease].

P Billoir1, V Le Cam Duchez1, S Miranda2

  • 1Inserm U1096, Vascular Hemostasis Unit, Rouen University Hospital, Normandie University, UNIROUEN, 76000 Rouen, France.

La Revue De Medecine Interne
|June 27, 2021
PubMed
Summary

The thrombin generation assay (TGA) can assess cardiovascular risk in autoimmune diseases (AID) by measuring hypercoagulable states. While underutilized, TGA shows potential for evaluating AID activity and thrombogenic treatments.

Keywords:
Auto immune diseaseHypercoagulabilityHypercoagulabilitéMaladie auto-immuneTest de génération de thrombineThrombin generation assay

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Area of Science:

  • Coagulation science
  • Immunology
  • Cardiovascular risk assessment

Background:

  • Thrombin generation assay (TGA) evaluates coagulation initiation, propagation, and inhibition.
  • TGA assesses hemorrhagic risk in hemophilia and hypercoagulable states.
  • Cardiovascular risk is linked to autoimmune diseases (AID) like antiphospholipid syndrome.

Purpose of the Study:

  • To explore the utility of TGA in evaluating cardiovascular risk in AID.
  • To assess TGA's role in hypercoagulable states associated with AID.
  • To investigate TGA's correlation with disease activity in specific AIDs.

Main Methods:

  • Utilized TGA to measure thrombin generation.
  • Compared TGA in antiphospholipid syndrome patients on rivaroxaban versus warfarin.
  • Measured TGA in rheumatoid arthritis, systemic lupus erythematosus, and Behçet's disease.

Main Results:

  • TGA identified hypercoagulability in antiphospholipid syndrome.
  • Elevated TGA was observed in rheumatoid arthritis, systemic lupus erythematosus, and Behçet's disease without thrombotic events.
  • TGA correlated with inflammatory activity in rheumatoid arthritis and disease activity in systemic lupus erythematosus and Behçet's disease.

Conclusions:

  • TGA is underutilized in clinical AID evaluation but shows potential.
  • TGA can help measure AID activity due to the coagulation-inflammation link.
  • Standardization is needed for broader TGA interpretation in AID.