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Cell death modulation by transient receptor potential melastatin channels TRPM2 and TRPM7 and their underlying

Ruixue Shi1, Yu Fu1, Dongyi Zhao2

  • 1Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China.

Biochemical Pharmacology
|June 27, 2021
PubMed

Insights

Transient receptor potential melastatin (TRPM) channels regulate cell death. This review explores TRPM channels

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Physiology

Background:

  • Transient receptor potential melastatin (TRPM) channels are integral membrane proteins mediating cation influx.
  • TRPM channels are crucial for cell proliferation, development, and cell death.
  • Diverse cell death modalities, including pyroptosis, necroptosis, and ferroptosis, have been identified.

Purpose of the Study:

  • To review various cell death modalities.
  • To summarize the role of TRPM channels, particularly TRPM2 and TRPM7, in different cell death types.
  • To discuss the regulatory mechanisms linking TRPM channels and cell death.

Main Methods:

  • Literature review of TRPM channels and cell death.
  • Analysis of TRPM channel involvement in cell death pathways.
  • Discussion of regulatory mechanisms.

Main Results:

  • TRPM channels act as upstream regulators in cell death signaling.
  • TRPM2 and TRPM7 are implicated in multiple cell death modalities.
  • Specific regulatory mechanisms connecting TRPM channels to cell death are elucidated.

Conclusions:

  • TRPM channels play a significant role in various cell death processes.
  • TRPM channels, especially TRPM2 and TRPM7, are key players in cell death.
  • TRPM channels represent potential therapeutic targets for cell death-related diseases.
Keywords:
ApoptosisAutophagyIon channelTRPMTherapeutic target

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