Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant
Yan Liang1, Ze-Yun Liu2, Ping-Yu Wang3
1Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, QingDao, ShanDong 266071, PR China; Department of Biochemistry and Molecular Biology, Binzhou Medical University, YanTai, ShanDong 264003, PR China.
Abstract:
The emergence of multidrug resistance (MDR) in malignant tumors is the primary reason for invalid chemotherapy. Antitumor drugs are often adversely affected by the MDR of tumor cells. Treatments using conventional drugs, which have specific drug targets, hardly regulate the complex signaling pathway of MDR cells because of the complex formation mechanism of MDR. However, natural products have positive advantages, such as high efficiency, low toxicity, and ability to target multiple mechanism pathways associated with MDR. Natural products, as MDR reversal agents, synergize with chemotherapeutics and enhance the sensitivity of tumor cells to chemotherapeutics, and the co-delivery of natural products and antitumor drugs with nanocarriers maximizes the synergistic effects against MDR in tumor cells. This review summarizes the molecular mechanisms of MDR, the advantages of natural products combined with chemotherapeutics in offsetting complicated MDR mechanisms, and the types and mechanisms of natural products that are potential MDR reversal modulators. Meanwhile, aiming at the low bioavailability of cocktail combined natural products and chemotherapeutic in vivo, the advantages of nanoplatform-based co-delivery system and recent research developments are illustrated on the basis of our previous research. Finally, prospective horizons are analyzed, which are expected to considerably improve the nano-co-delivery of natural products and chemotherapeutic systems for MDR reversal in cancer.
Insights
Natural products can reverse multidrug resistance (MDR) in cancer by synergizing with chemotherapy. Nanocarrier systems enhance the effectiveness of co-delivered natural products and chemotherapy for improved cancer treatment outcomes.
Area of Science:
- Oncology
- Pharmacology
- Nanotechnology
Background:
- Multidrug resistance (MDR) in malignant tumors significantly limits chemotherapy efficacy.
- Conventional chemotherapeutics struggle to overcome complex MDR mechanisms due to specific drug targets.
- MDR poses a major challenge in cancer treatment, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the molecular mechanisms underlying MDR in cancer.
- To explore the advantages of natural products as MDR reversal agents.
- To highlight the potential of nanoplatform-based co-delivery systems for enhancing MDR reversal therapy.
Main Methods:
- Comprehensive literature review on MDR mechanisms and natural product-based reversal strategies.
- Analysis of the synergistic effects of combining natural products with chemotherapeutics.
- Evaluation of nanocarrier systems for co-delivery of natural products and antitumor drugs.
Main Results:
- Natural products exhibit high efficiency, low toxicity, and multi-target capabilities beneficial for MDR reversal.
- Co-delivery of natural products and chemotherapeutics via nanocarriers maximizes synergistic effects against MDR.
- Nanoplatforms improve the in vivo bioavailability of combined natural products and chemotherapeutics.
Conclusions:
- Natural products are promising MDR reversal agents that can enhance chemotherapy sensitivity.
- Nanotechnology-based co-delivery systems offer a potent strategy to overcome MDR in cancer.
- Further research into nano-co-delivery systems holds significant promise for improving cancer treatment outcomes.
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