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Long non-coding RNAs and their involvement in bipolar disorders.

Fabrizio Bella1, Salvatore Campo1

  • 1Department of Biomedical and Dental Sciences and Morphofunctional Images, University of Messina, via Consolare Valeria, 1, Messina 98125 Italy.

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Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression. Dysregulation of lncRNAs is implicated in bipolar disorders, particularly those affecting inflammation and neuronal development.

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Bipolar disordersLong non-coding RNAsMolecular geneticsMood disorders

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Area of Science:

  • Molecular Biology
  • Genetics
  • Neuroscience

Background:

  • Non-coding RNAs (nc-RNAs) are RNA molecules not translated into proteins.
  • Regulatory nc-RNAs include short non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs).
  • lncRNAs, exceeding 200 bp, regulate gene expression in various cellular compartments and tissues.

Purpose of the Study:

  • To review genes, classification, biogenesis, structures, functions, and databases of lncRNAs.
  • To focus on the role of lncRNAs in bipolar disorders.
  • To highlight lncRNAs involved in inflammation and neuronal development in the context of bipolar disorder.

Main Methods:

  • Literature review of lncRNA research.
  • Analysis of lncRNA involvement in gene regulation.
  • Examination of evidence linking lncRNA dysregulation to bipolar disorder pathophysiology.

Main Results:

  • lncRNAs play significant roles in cellular physiology and pathology.
  • Disruption of lncRNA regulatory functions is observed in various diseases.
  • Specific lncRNAs involved in inflammation and neuronal development show dysregulation in bipolar disorders.

Conclusions:

  • lncRNAs are critical regulators with diverse functions.
  • Altered lncRNA expression is a potential factor in bipolar disorder.
  • Further research into lncRNAs may offer insights into bipolar disorder mechanisms and treatments.