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Related Experiment Video

Updated: Nov 1, 2025

Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish

Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish

Published on: December 21, 2016

Interrenal development and function in zebrafish.

Irina Bacila¹, Vincent T Cunliffe², Nils P Krone³

¹Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom; The Bateson Centre, Firth Court, Western Bank, Sheffield, S10 2TN, United Kingdom.

Molecular and Cellular Endocrinology

|June 27, 2021

Summary

This summary is machine-generated.

Zebrafish interrenal gland development and function are reviewed, highlighting their utility in studying steroidogenesis and related human diseases. Genetic models reveal impacts of steroid biosynthesis defects.

Keywords:

Animal model Cortisol deficiency Steroid biosynthesis Steroidogenic enzymes Zebrafish interrenal gland

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Area of Science:

Developmental Biology
Endocrinology
Comparative Genomics

Background:

The interrenal gland is crucial for steroid hormone production in vertebrates.
Zebrafish offer a powerful model for studying endocrine development and function due to genetic tractability and physiological similarities to mammals.
Understanding interrenal development is key to addressing endocrine disorders.

Purpose of the Study:

To provide a comprehensive overview of zebrafish interrenal gland development and function.
To review the role of zebrafish in basic and translational research concerning steroidogenesis.
To highlight the impact of genetic and environmental factors on steroid biosynthesis.

Main Methods:

Systematic literature search of PubMed for relevant studies over the past 20 years.
Analysis of organogenesis and functional development of the interrenal gland.
Review of genes involved in zebrafish steroidogenesis and consequences of their defects.

Main Results:

Identified 41 relevant papers, synthesizing information on interrenal organogenesis and functional development.
Detailed the genes and pathways regulating zebrafish steroidogenesis.
Illustrated the effects of specific gene deficiencies (cyp11a2, cyp21a2, hsd3b1, cyp11c1, fdx1b) on steroid biosynthesis.
Summarized the influence of chemical and environmental factors on steroidogenesis.

Conclusions:

Zebrafish serve as an excellent model for investigating fundamental aspects of steroidogenesis and human endocrine diseases.
Genetic engineering in zebrafish provides valuable insights into the consequences of steroid biosynthesis defects.
The utility of zebrafish in research is enhanced by advancements in Molecular Biology.