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Surgical Wound Complications after Colorectal Surgery with Single-Use Negative-Pressure Wound Therapy Versus Surgical
Miguel León Arellano1, Cristina Barragán Serrano, Manuela Guedea
1In the Department of General and Digestive Surgery at the Hospital Fundación Jimenez Diaz, Madrid, Spain, Miguel León Arellano, MD, is Colorectal Surgeon; and Cristina Barragán Serrano, MD, is Surgeon, Esophagogastric Unit. Manuela Guedea, MD, is Surgeon, General and Digestive Surgery, Hospital Clinico Universitario Lozano Blesa, Zaragoza. Juan Carlos Garcia Pérez, MD, is General Surgeon, General and Digestive Surgery, Hospital Ramón y Cajal, Madrid. Gonzalo Sanz Ortega, MD, is Surgeon, General and Digestive Surgery, Hospital Clínico San Carlos, Madrid. Jenny Guevara-Martinez, MD, is General and Digestive Surgeon, Hospital Universitario La Paz, Madrid. Segundo Gomez Abril, MD, is Clinical Chief, General and Digestive Surgery, Hospital Doctor Pesset, Valencia. Cristina González Puga, MD, is Surgeon, General and Digestive Surgery, Hospital San Cecilio, Granada. Antonio Arroyo, PhD, MD, is Chief of Surgery, General and Digestive Surgery, Hospital Elche, Elche. Ramón Cantero Cid, PhD, MD, is Professor of Medical Sciences, Universidad Autónoma, Madrid. Acknowledgments: This study was sponsored by PREVENA Incision Management System, KCI, San Antonio, Texas, who provided the closed-incision negative-pressure therapy devices. The authors have disclosed no other financial relationships related to this article. Submitted October 15, 2020; accepted in revised form January 7, 2021; published online ahead of print June 26, 2021.
Background:
Global studies indicate that surgical site infections (SSIs) are a major healthcare challenge within hospitals and can have a profound impact on patient quality of life and healthcare costs. Closed-incision negative-pressure therapy (ciNPT) has been reported to provide positive clinical benefits for patients with various incisions, including those following colorectal surgeries.
Methods:
Investigators performed a prospective, randomized, multicenter trial to evaluate complications of surgical incisions in patients who received a ciNPT dressing versus a conventional surgical dressing (control) over their closed incision following colorectal surgery. The incidence of SSI was determined at 7, 15, and 30 days postsurgery.
Results:
A total of 148 patients participated in the study. Results showed that the SSI rate on day 7 was lower in the ciNPT group versus the control group (10/75 [13.3%] vs 17/73 [23.3%]), but this difference was not statistically significant. On day 15, the SSI rate was 12/75 (16.0%) in the ciNPT group versus 21/73 (28.8%) in the control group; however, this difference was only marginally statistically significant (P = .0621). At 1 month, the SSI rate remained lower in the ciNPT group (13/75 [17.3%] vs 21/73 [28.8%], P = .0983) compared with the control group.
Conclusions:
Future studies with larger population sizes are necessary to determine the impact of ciNPT on patients' incisions after colorectal surgery.
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