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Types of Radioactivity

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The most common types of radioactivity are α decay, β decay, γ decay, neutron emission, and electron capture.
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Applications Of NMR In Biology

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Updated: Nov 1, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Why bother with alpha particles?

A Paden King1,2, Frank I Lin1, Freddy E Escorcia3,4

  • 1Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20817, USA.

European Journal of Nuclear Medicine and Molecular Imaging
|June 27, 2021
PubMed
Summary
This summary is machine-generated.

Alpha-particle therapy shows promise for cancer treatment, with many new radiopharmaceuticals entering clinical trials. This review covers alpha-emitter principles, recent advances, and challenges for wider clinical use.

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Area of Science:

  • Nuclear medicine
  • Radiopharmaceutical therapy
  • Oncology

Background:

  • The 2013 approval of radium-223 chloride (223RaCl2) spurred renewed interest in alpha-particle emitting radiopharmaceuticals for cancer treatment.
  • Over a dozen alpha-emitting radiopharmaceuticals have advanced to clinical trials in the past decade, driven by promising preclinical data.

Purpose of the Study:

  • To explore the therapeutic potential of alpha-particle therapy in oncology.
  • To review the fundamental principles of alpha-emitter therapy.
  • To discuss recent advancements and clinical challenges in alpha-particle therapy.

Main Methods:

  • Review of scientific literature on alpha-particle emitting radiopharmaceuticals.
  • Analysis of preclinical and clinical study data.
  • Discussion of therapeutic principles and emerging strategies.

Main Results:

  • Significant progress has been made in developing alpha-emitting radiopharmaceuticals, including conjugates with small molecules and antibodies.
  • Several alpha-emitting agents are now in clinical trials for various cancers.
  • The therapeutic efficacy of alpha-particle therapy is supported by strong preclinical evidence.

Conclusions:

  • Alpha-particle therapy represents a promising modality for cancer treatment.
  • Further research and development are needed to overcome challenges in clinical adoption.
  • Targeted delivery and optimized dosimetry are key areas for future advancements.