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Identification of a polypeptide associated with the malignant phenotype in acute leukemia
S M Hanash1, J R Strahler, R Kuick
1Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109.
The Journal of Biological Chemistry
|September 15, 1988
Abstract:
A novel polypeptide, designated p18, was detected in a variety of hematopoietic cells by two-dimensional polyacrylamide gel electrophoresis. Quantitative analysis of p18 indicated its occurrence in a substantially greater amount in acute leukemia relative to nonleukemic cells. The increased amount of p18 in leukemia could not be explained on the basis of specific lineage, differentiation stage, or cell proliferation and thus appears to be a part of the malignant phenotype of the leukemic cells.