Related Experiment Video
Updated: Nov 1, 2025
Laser-Induced Chronic Ocular Hypertension Model on SD Rats
Published on: December 4, 2007
Glycosides from Buddleja officinalis with their protective effects on photoreceptor cells in light-damaged mouse
Zehai Long1, Xiaoye Du2,3, Qiyao Wang1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Abstract:
A new phenylethanoid, hebitol IV (1), along with fifteen known glycosides (2-16), were isolated from water extract of the flower buds of Buddleja officinalis. Their structures were elucidated on the basis of 1 D-NMR, 2 D-NMR and MS data. Molecular docking showed the potential activities of the natural products against VEGFR-2. Bioassay results revealed that the compounds 10 and 14 exhibited strong inhibitory activity against VEGFR-2 with IC50 values of 0.51 and 0.32 μM, respectively. Moreover, the potential retinal protective effects of 10 and 14 were then investigated in the mouse model featuring bright light-induced retinal degeneration. The results demonstrated remarkable photoreceptor protective activities of 10 and 14 in vivo.
