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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Folliculogenesis01:20

Folliculogenesis

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Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
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Related Experiment Video

Updated: Nov 1, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

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Follicular lymphoma dynamics.

Pierre Milpied1, Anita K Gandhi2, Guillaume Cartron3

  • 1Aix Marseille University, CNRS, INSERM, CIML, Marseille, France.

Advances in Immunology
|June 28, 2021
PubMed
Summary
This summary is machine-generated.

Follicular lymphoma (FL) remains challenging due to treatment resistance. Understanding the evolving tumor-microenvironment interactions is key to developing new therapies for relapsed and refractory FL.

Keywords:
Cell of origin (COO)Committed precursor cell (CPC)Follicular lymphoma (FL)PlasticitySingle-cell RNA-seqTumor microenvironmentUnmet medical need

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Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
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Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
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Area of Science:

  • Hematology
  • Oncology
  • Cancer Biology

Background:

  • Follicular lymphoma (FL) is an indolent lymphoma with frequent relapses and increasing treatment resistance.
  • Current immunochemotherapy is effective for many, but a subset of patients experiences early relapse or refractoriness.
  • Understanding the biology of treatment-resistant FL and early progression is crucial for clinical management.

Purpose of the Study:

  • To explore the genomic and microenvironmental factors contributing to follicular lymphoma progression and treatment resistance.
  • To investigate the heterogeneity and plasticity of FL cells within their tumor microenvironment (TME).
  • To identify novel therapeutic strategies by understanding the complex tumor-TME dynamics in FL.

Main Methods:

  • Analysis of the (epi)genomic landscape of FL cells.
  • Interrogation of the tumor microenvironment (TME) and its role in lymphomagenesis.
  • Application of single-cell technologies to decipher cellular heterogeneity and dynamics.

Main Results:

  • FL pathogenesis involves a complex interplay between evolving tumor cells and the TME.
  • Significant clonal and functional heterogeneity exists within FL, complicating biomarker discovery.
  • Single-cell analyses reveal unexpected cell dynamics and plasticity in FL.

Conclusions:

  • A deeper understanding of FL biology, particularly tumor-TME interactions and cellular heterogeneity, is emerging.
  • Novel technological approaches are crucial for unraveling FL complexity.
  • Addressing unmet medical needs in FL requires a comprehensive functional picture of the lymphoma ecosystem.