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Updated: Nov 1, 2025

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
Published on: January 21, 2017
Neurobiology of brain oscillations in acute and chronic pain
Linette Liqi Tan1, Manfred Josef Oswald1, Rohini Kuner1
1Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, D-69120 Heidelberg, Germany.
Abstract:
Pain is a complex perceptual phenomenon. Coordinated activity among local and distant brain networks is a central element of the neural underpinnings of pain. Brain oscillatory rhythms across diverse frequency ranges provide a functional substrate for coordinating activity across local neuronal ensembles and anatomically distant brain areas in pain networks. This review addresses parallels between insights from human and rodent analyses of oscillatory rhythms in acute and chronic pain and discusses recent rodent-based studies that have shed light on mechanistic underpinnings of brain oscillatory dynamics in pain-related behaviors. We highlight the potential for therapeutic modulation of oscillatory rhythms, and identify outstanding questions and challenges to be addressed in future research.
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