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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
Screening High-Risk Women Veterans for Breast Cancer
Yeun-Hee Anna Park1, Alison Keller1, Ta-Chueh Melody Hsu1
1is Chief of Hematology/Oncology; is a Research Coordinator; and is a Research Nurse Practitioner, all at James J. Peters Veterans Affairs Medical Center, Bronx, New York. is an Industrial Engineer VA Center for Applied Systems Engineering (VA-CASE), VISN11 - Veterans Engineering Resource Center (VERC) at Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana. was a Senior Genetic Counselor for the US Department of Veterans Affairs (VA) Genomic Medicine Services, and is a Hematologist/Oncologist; both at George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, Utah. is a Hematologist/Oncologist at Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio. is a ONS Clinical Nurse Advisor for the Oncology Field Advisory Committee and VHA National Program Manager for Prevention Policy at Veterans Health Administration (VHA) National Center for Health Promotion and Disease Prevention, Durham, North Carolina and VHA Office of Nursing Services, Washington, DC. is a Program Manager at Veterans Health Administration, Pharmacy Benefits Management Services in Hines, Illinois. is a Hematologist/Oncologist Washington Veterans Affairs Medical Center, Washington, DC.
This study found a high percentage of Black women veterans at increased risk for breast cancer, with many also experiencing posttraumatic stress disorder (PTSD). Further research is needed to understand these risks in this underrepresented population.
Area of Science:
- Oncology
- Public Health
- Veterans Health
Background:
- Breast cancer prevalence has significantly increased among US Department of Veterans Affairs (VA) patients.
- Women veterans may face elevated breast cancer risks due to service exposures and posttraumatic stress disorder (PTSD).
Purpose of the Study:
- To assess 5-year and lifetime invasive breast cancer risks in women veterans using the Gail Breast Cancer Risk Assessment Tool (BCRAT).
- To gather data on demographics, PTSD, chemoprevention eligibility, and genetic counseling needs within this population.
Main Methods:
- Enrolled women veterans aged 35+ with no prior breast cancer history at two urban VA medical centers.
- Administered BCRAT surveys and collected data on demographics, PTSD, and other relevant factors.
- Utilized descriptive statistics to analyze the collected data.
Main Results:
- Ninety-nine women veterans participated; 60% were Black, and 35% were identified as high-risk (>1.66% 5-year BCRAT).
- High-risk Black women veterans showed high rates of prior breast biopsies (33%) and family history (94%).
- 31% of the high-risk subgroup had PTSD; some were referred for chemoprevention and genetic counseling.
Conclusions:
- The pilot study highlighted significant breast cancer risk and PTSD prevalence in participating Black women veterans.
- High participation of Black women veterans suggests potential for future research in this underrepresented group.
- Future research should explore genetic mutations and PTSD epigenetic changes in high-risk Black women veterans.
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