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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Nov 1, 2025

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii
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Toxoplasma gondii, Suicidal Behavior, and Intermediate Phenotypes for Suicidal Behavior.

Teodor T Postolache1,2,3, Abhishek Wadhawan1,4, Dan Rujescu5

  • 1Department of Psychiatry, Mood and Anxiety Program, University of Maryland School of Medicine, Baltimore, MD, United States.

Frontiers in Psychiatry
|June 28, 2021
PubMed
Summary
This summary is machine-generated.

Infection with Toxoplasma gondii (T. gondii) is linked to a higher risk of suicide attempts, but not suicidal ideation. Further research is needed to confirm causality and explore potential treatments for T. gondii-associated suicide risk.

Keywords:
Toxoplasma gondiiaggressionimpulsivityself-directed violencesuicidal behaviorsuicidesuicide attempts

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Area of Science:

  • Neuroparasitology
  • Psychiatry
  • Infectious Diseases

Background:

  • Toxoplasma gondii (T. gondii) infection is prevalent and affects behavior due to its neurotropism.
  • Studies suggest T. gondii is associated with increased risk-taking, aggression, mental illness, and suicidal behavior.
  • This review focuses on the link between T. gondii serology and suicidal behavior.

Purpose of the Study:

  • To review the association between T. gondii serology and suicidal behavior.
  • To present primary studies and meta-analyses on T. gondii and suicide risk.
  • To explore potential biological mechanisms and intermediate phenotypes linking T. gondii to suicidal behavior.

Main Methods:

  • Review of primary studies on T. gondii IgG serology in individuals with mood disorders, schizophrenia, and recent suicide attempters.
  • Analysis of three published meta-analyses on T. gondii and suicidal behavior.
  • Examination of T. gondii associations with biomarkers and intermediate phenotypes of suicidal behavior.

Main Results:

  • Consistent evidence shows a 39-57% increased odds of suicide attempts in T. gondii IgG-positive individuals.
  • The association is specific to suicide attempts, not suicidal ideation, and linked to T. gondii IgG, not IgM.
  • T. gondii seropositivity is also associated with impulsivity and aggression, endophenotypes of suicidal behavior.

Conclusions:

  • Abundant evidence supports a link between T. gondii IgG seropositivity and suicide attempts.
  • Causality has not been established, necessitating randomized interventional studies.
  • If causality is confirmed, T. gondii infection may represent a treatable etiological factor for suicide risk in a specific population.