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GnRHa/Stanozolol Combined Therapy Maintains Normal Bone Growth in Central Precocious Puberty

Shunye Zhu1, Lingli Long2, Yue Hu2

  • 1Department of Pediatrics, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Frontiers in Endocrinology
|June 28, 2021
PubMed

Insights

Stanozolol (ST) prevents growth deceleration caused by Gonadotropin-releasing hormone agonist (GnRHa) treatment in rats. ST promotes chondrogenic differentiation and maintains growth plate development via the JNK/Sox9 pathway.

Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Bone Biology

Background:

  • Gonadotropin-releasing hormone agonist (GnRHa) is standard for Central Precocious Puberty (CPP), but can impede growth.
  • GnRHa treatment may cause growth deceleration and inhibit growth plate development, reducing height velocity.

Purpose of the Study:

  • To investigate the effects and mechanisms of Stanozolol (ST) on growth plate development in rats treated with GnRHa for CPP.

Main Methods:

  • Rats with GnRHa-induced CPP were treated with ST.
  • Chondrogenic differentiation and growth plate development were assessed.
  • The involvement of the JNK/c-Jun/Sox9 signaling pathway was analyzed.

Main Results:

  • ST prevented growth deceleration and maintained normal growth plate development in GnRHa-treated rats.
  • ST counteracted GnRHa's inhibitory effects, promoting chondrogenic differentiation.
  • ST activated the JNK/c-Jun/Sox9 pathway, facilitating chondrogenesis and growth plate development.

Conclusions:

  • Stanozolol mitigates GnRHa's negative impact on growth in a rat model of CPP.
  • ST promotes chondrocyte differentiation and preserves growth plate integrity via the JNK/Sox9 pathway.
  • ST shows potential as an adjunct therapy to maintain bone growth in CPP patients receiving GnRHa treatment.
Abstract

Keywords:
CPPGnRHaSTbone growthchondrogenic differentiation

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