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Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research
1Schepens Eye Research Institute of Mass Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School, Boston, MA, United States.
Abstract:
We are currently experiencing a deadly novel viral pandemic with no efficacious, readily available anti-viral therapies to SARS-CoV-2. Viruses will hijack host cellular machinery, including metabolic processes. Here, I provide theory and evidence for targeting the host de novo purine synthetic pathway for broad spectrum anti-viral drug development as well as the pursuit of basic science to mitigate the risks of future novel viral outbreaks.
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