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Updated: Nov 1, 2025

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
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Asymmetric Somatic Hybridization Affects Synonymous Codon Usage Bias in Wheat.

Wenjing Xu1, Yingchun Li1, Yajing Li1

  • 1The Key Laboratory of Plant Development and Environmental Adaption, Ministry of Education, School of Life Science, Shandong University, Jinan, China.

Frontiers in Genetics
|June 28, 2021
PubMed
Summary

Asymmetric somatic hybridization shifts synonymous codon usage bias (SCUB) in wheat, driven by whole genome shock, not local DNA. DNA methylation plays a key role in this genetic variation.

Keywords:
genomic shockintrogression linesomatic hybridizationsynonymous codon usage biaswheat

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Area of Science:

  • Plant Genetics and Breeding
  • Molecular Biology
  • Genomics

Background:

  • Asymmetric somatic hybridization induces genetic variation in crops.
  • Synonymous codon usage bias (SCUB) reflects genomic mutation and selection.
  • The impact of asymmetric somatic hybridization on SCUB remains unexplored.

Purpose of the Study:

  • To investigate how asymmetric somatic hybridization influences SCUB in common wheat.
  • To determine the role of genomic shock and DNA methylation in SCUB shifts.

Main Methods:

  • Comparative analysis of expressed sequence tags (ESTs) from wheat and its somatic hybrid.
  • Evaluation of SCUB frequencies across different genomic regions and chromosome types.
  • Assessment of DNA methylation's influence on SCUB.

Main Results:

  • Asymmetric somatic hybridization altered SCUB, favoring A- and T-ending codons.
  • Exogenous chromatin fragments did not cause local SCUB effects.
  • SCUB shifts were more pronounced near indels and influenced by DNA methylation.

Conclusions:

  • Whole genome shock, not local chromosomal changes, drives SCUB shifts post-hybridization.
  • DNA methylation is a significant factor in SCUB alteration during this process.
  • Asymmetric somatic hybridization offers insights into SCUB and genomic shock mechanisms.