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Pediatric Multisystem Inflammatory Syndrome in Children as a Challenging Problem for Pediatric Surgeons in the COVID
Beata Jurkiewicz1, Magdalena Szymanek-Szwed1, Piotr Hartmann2
1Department of Pediatric Surgery and Pediatric Urology, Medical Center of Postgraduate Education, Dziekanów Leśny, Poland.
Insights
Pediatric inflammatory multisystem syndrome (PIMS-TS) can cause severe abdominal symptoms mimicking surgical emergencies in children infected with SARS-CoV-2. Early consideration of PIMS-TS is crucial for accurate diagnosis and timely management in pediatric patients.
Area of Science:
- Pediatric Infectious Diseases
- Pediatric Surgery
- Critical Care Medicine
Background:
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily impacted adults, with children often experiencing milder symptoms.
- Emergence of pediatric inflammatory multisystem syndrome (PIMS-TS) in children post-SARS-CoV-2 infection, presenting with severe systemic inflammation.
- PIMS-TS can manifest with symptoms suggestive of surgical emergencies, complicating diagnosis and management.
Observation:
- A case report details an 11-year-old boy with severe abdominal pain and peritonitis symptoms requiring surgery.
- Post-operative diagnosis revealed PIMS-TS, highlighting the syndrome's potential surgical presentations.
- Symptoms included severe abdominal pain, peritoneal signs, ascites, elevated inflammatory markers, and intestinal inflammation.
Findings:
- PIMS-TS can present with acute abdominal symptoms, mimicking surgical conditions like appendicitis or peritonitis.
- The syndrome carries a significant mortality rate (up to 2%) and requires prompt recognition.
- Diagnostic challenges arise due to the overlap of gastrointestinal and inflammatory symptoms.
Implications:
- PIMS-TS should be included in the differential diagnosis for acute abdominal pain in children, especially with a history of SARS-CoV-2 exposure.
- Increased awareness among pediatricians and surgeons is vital for timely diagnosis and appropriate treatment strategies.
- Further research is needed to elucidate the pathophysiology and optimize management protocols for PIMS-TS with surgical manifestations.
Abstract:
The first cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection were identified at the end of 2019 and, in the next few months, coronavirus disease (COVID-19) spread throughout the world. Initially, it was believed that this disease mainly affected elderly individuals with comorbidities, in whom respiratory failure often occurs. It was believed that children fell ill from the infection more often, although the course of infection in the vast majority of pediatric cases has been asymptomatic or mildly symptomatic. In April and May 2020, the first report of a rapidly progressing disease, similar to Kawasaki syndrome, was found in children who had been infected with SARS-CoV-2. Shortly thereafter, children with symptoms of pediatric inflammatory multisystem syndrome (PIMS-ST [temporally associated with SARS-CoV-2 infection]) began presenting to pediatric hospitals around the world. The syndrome has a mortality rate of up to 2%. Symptoms of PIMS-TS include those that may suggest the need for surgical treatment (severe abdominal pain with the presence of peritoneal symptoms, ascites, high levels of inflammatory markers, intestinal inflammation, and appendages revealed on ultrasound examination). However, there are few reports addressing surgical cases associated with this condition. The authors present a case involving an 11-year-old boy who was admitted to hospital with severe abdominal pain and underwent surgery for symptoms of peritonitis and was diagnosed with PIMS in the post-operative period. Due to the large number of illnesses caused by SARS-CoV-2 infection in recent months, the diagnosis of PIMS-TS/MISC should be considered in the differential diagnosis of acute abdominal symptoms, especially in atypical courses and interviews indicating exposure to SARS-CoV-2.
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