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Crystallographic Pattern Mediates Fungal Nanoadhesion Bond Formation on Titanium Nanotubes
Benjamín Valdez-Salas1,2, Ernesto Beltrán-Partida1,2, Mario Curiel-Álvarez2
1Laboratorio de Biología Molecular y Cáncer, Instituto de Ingeniería, Universidad Autónoma de Baja California, Blvd. Benito Juárez y Calle de la Normal, Mexicali, Baja California C.P. 21280, México.
ACS Omega
|June 28, 2021
Summary
Blocking fungal nanoadhesion bonds is key to preventing Candida albicans adhesion. Amorphous nanotube (NTs) surfaces effectively inhibit fungal colonization by disrupting these bonds, offering a promising strategy for antifungal coatings.
Area of Science:
- Materials Science
- Biotechnology
- Mycology
Background:
- Nanoadhesion bonds at the cell-material biointerface are implicated in microbial adhesion and colonization.
- There is a need for rationally designed antifungal nanoconfigured materials.
- Inhibiting fungal nanoadhesion bonds is crucial for blocking Candida albicans adhesion and biofilm formation.
Purpose of the Study:
- To investigate the antifungal behavior of different nanotube (NTs) crystallographic phases (anatase vs. amorphous).
- To determine the predominant parameter controlling antifungal activity: crystallographic orientation, surface roughness, or chemistry.
- To understand how NTs configurations affect C. albicans adhesion and biofilm formation.
Main Methods:
- Fabrication and characterization of anatase (NTs-annealed) and amorphous NTs.
- Evaluation of C. albicans adhesion and biofilm formation on different NTs surfaces.
- Analysis of nanoadhesion bond formation and surface energy under fungal conditions.
- Cross-sectioning to visualize nanoadhesion bond development within NTs.
Main Results:
- Crystallographic orientation is a predominant factor in reducing C. albicans adhesion, surpassing surface roughness and chemistry.
- The anatase phase promoted an invasive fungal phenotype with cellular envelopment and spread.
- Amorphous NTs significantly reduced nanoadhesion bonds, particularly at the NTs mouths, inhibiting C. albicans deposition without causing morphological aberrations.
Conclusions:
- Crystallographic pattern predominantly controls the antifungal activity of NTs.
- Amorphous NTs inhibit C. albicans deposition by blocking nanoadhesion bond development.
- These findings can guide the rational design of nanoconfigured surfaces for advanced antimicrobial coating technologies.
