Related Experiment Video

Updated: Oct 31, 2025

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.7K

Multiple Etiologies to Myocardial Injury in COVID-19

Miroslawa Gorecka1, Sharmaine Thirunavukarasu1, Eylem Levelt1

  • 1Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.

JACC. Case Reports
|June 28, 2021
PubMed

Insights

Coronavirus disease-2019 (COVID-19) can cause acute myocardial injury. Cardiovascular magnetic resonance imaging revealed both epicardial and microvascular thrombosis in a COVID-19 patient, identifying the cardiac pathology.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • Acute myocardial injury is a recognized complication of coronavirus disease-2019 (COVID-19).
  • The specific cardiovascular pathologies underlying COVID-19-related myocardial injury require further elucidation.
  • Cardiovascular magnetic resonance imaging (CMR) is a valuable tool for assessing cardiac structure and function.

Purpose of the Study:

  • To describe a case of acute myocardial injury secondary to COVID-19.
  • To illustrate the utility of cardiovascular magnetic resonance imaging in identifying cardiac pathology in COVID-19.
  • To highlight the presence of both epicardial and microvascular thrombosis in a patient with COVID-19-related myocardial injury.

Main Methods:

  • Case report of a patient with confirmed COVID-19 and acute myocardial injury.
  • Detailed cardiovascular magnetic resonance imaging (CMR) examination.
  • Analysis of CMR findings to identify thrombotic events.

Main Results:

  • Cardiovascular magnetic resonance imaging identified acute myocardial injury in the patient.
  • Findings included thrombosis in an epicardial coronary vessel.
  • Evidence of microvascular thrombosis, a recently described phenomenon, was also observed.

Conclusions:

  • Cardiovascular magnetic resonance imaging is effective in diagnosing myocardial injury in COVID-19 patients.
  • COVID-19 can lead to complex thrombotic events affecting both large epicardial vessels and smaller microvasculature.
  • This case underscores the diverse cardiovascular manifestations of COVID-19.

Keywords:
CMR, cardiac magnetic resonance imagingCOVID-19, coronavirus-2019cardiac magnetic resonancemyocardial infarctionthrombosis

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.3K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.7K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
115
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
68
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
42
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
166
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
198
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
99