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Updated: Oct 31, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Risk factors associated with postpartum depression in a high-risk maternity clinic: a cross-sectional study
Kelly C Machado Ramos1,2, Cristine K Konopka1,2, Arthur G Costa2
1Unit of Gynecology and Obstetrics, Health Sciences Center, University Hospital of Santa Maria, Federal University of Santa Maria, Santa Maria, Brazil.
Postpartum depression (PPD) affects nearly 30% of mothers. Depression during pregnancy significantly increases PPD risk, while breastfeeding without complications is protective. Early detection and treatment are crucial.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Mental Health
- Epidemiology
Background:
- Postpartum depression (PPD) presents a significant challenge for maternal health.
- Identifying obstetric, epidemiological, and social factors is crucial for understanding PPD.
- This study focuses on puerperal women referred to a High-Risk Outpatient Clinic.
Purpose of the Study:
- To evaluate factors associated with postpartum depression (PPD).
- To investigate potential risk factors for PPD in high-risk postpartum women.
- To assess the impact of obstetric, epidemiological, and social variables on PPD development.
Main Methods:
- A cross-sectional study was conducted from August to December 2019.
- 171 postpartum women completed an epidemiological questionnaire and the Edinburgh Postpartum Depression Scale (EPDS).
- Scores of 10 or higher on the EPDS indicated positive PPD screening.
Main Results:
- 29.8% of mothers screened positive for PPD.
- Factors associated with PPD include unplanned pregnancy, personal history of depression, and family history of depression.
- Depression during pregnancy was a significant risk factor, increasing PPD risk by 12 times (OR=12.891).
- Breastfeeding without complications demonstrated a protective effect against PPD (P=0.002).
Conclusions:
- Depression during pregnancy is a critical risk factor for developing postpartum depression.
- The Edinburgh Postpartum Depression Scale (EPDS) is effective for early detection of PPD.
- Timely intervention and treatment are essential for managing PPD.
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