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Updated: Oct 31, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Aggressive Cyclin D1 Negative Blastoid Variant Mantle Cell Lymphoma-A Case Report.

Lavina Loungani¹, Rajesh Mundhe¹, Roshan Chinoy¹

¹72939Prince Aly Khan Hospital, Mumbai, Maharashtra, India.

International Journal of Surgical Pathology

|June 28, 2021

Summary

This case study identifies a rare, aggressive blastoid variant of mantle cell lymphoma (MCL) lacking cyclin D1 but expressing SOX11. This finding underscores the importance of SOX11 in diagnosing challenging MCL subtypes.

Area of Science:

Hematopathology
Oncology
Molecular Diagnostics

Background:

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma.

Keywords:

SOX11 blastoid cyclin D1 lymphoma mantle

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While classic MCL morphology is common, variants exist, some with aggressive clinical behavior.

Cyclin D1 negativity can occur in MCL variants, posing diagnostic challenges.