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Updated: Oct 31, 2025

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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Aggressive Cyclin D1 Negative Blastoid Variant Mantle Cell Lymphoma-A Case Report
Lavina Loungani1, Rajesh Mundhe1, Roshan Chinoy1
172939Prince Aly Khan Hospital, Mumbai, Maharashtra, India.
International Journal of Surgical Pathology
|June 28, 2021
Summary
This case study identifies a rare, aggressive blastoid variant of mantle cell lymphoma (MCL) lacking cyclin D1 but expressing SOX11. This finding underscores the importance of SOX11 in diagnosing challenging MCL subtypes.
Area of Science:
- Hematopathology
- Oncology
- Molecular Diagnostics
Background:
- Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma.
- While classic MCL morphology is common, variants exist, some with aggressive clinical behavior.
- Cyclin D1 negativity can occur in MCL variants, posing diagnostic challenges.

