Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute cholangitis: a histopathologic study.

H Shimada1, S Nihmoto, A Matsuba

  • 1First Department of Surgery, Fukui Medical School, Japan.

Journal of Clinical Gastroenterology
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sialyl-lewis-x antigen immunoreaction of colorectal-cancer and its relationship to hematogenous metastasis.

Oncology reports·2011
Same author

Significance of tumor marker SLX in colorectal cancer.

Oncology reports·2011
Same author

Colonic prostaglandin-e2 in carcinogenesis in rats with N-methyl-n'-nitrosoguanidine.

International journal of oncology·2011
Same author

Bcl-2 protein expression in breast cancer and its relationship to prognosis.

International journal of oncology·2011
Same author

Lectin-histochemical reactivity of sialic acid in breast cancer and its relationship to prognosis using limulus polyphemus agglutinin.

International journal of oncology·2011
Same author

Inhibition of liver metastasis formation by anti-CD44 variant exon 9 monoclonal antibody.

International journal of oncology·2011

Histological examination of the liver in acute cholangitis reveals that neutrophilic infiltration and microabscesses are characteristic of severe cases. These microscopic findings correlate with clinical severity and patient outcomes.

Area of Science:

  • Hepatology
  • Pathology
  • Infectious Diseases

Background:

  • Acute cholangitis is a serious liver infection.
  • Understanding histological changes is crucial for assessing disease severity.

Purpose of the Study:

  • To correlate liver histology in acute cholangitis with clinical status.
  • To identify specific microscopic findings indicative of severe disease.

Main Methods:

  • Histological examination of liver tissue from 34 acute cholangitis patients.
  • Clinical classification into mild and severe cases.
  • Analysis of microscopic findings against clinical severity.

Main Results:

  • Severe cholangitis cases showed higher rates of endotoxemia, bacteremia, disseminated intravascular coagulation (DIC), and hepatic failure.

Related Experiment Videos

  • Neutrophile infiltration into sinusoids and lobular microabscesses were significantly more frequent in severe cases.
  • Portal thrombosis and massive hepatic cell necrosis were also higher in severe cases, particularly in non-survivors.

    • Conclusions:

    • Neutrophilic infiltration and microabscesses are characteristic histological findings in severe acute cholangitis.
    • These microscopic changes correlate with clinical severity and patient prognosis.
    • Histopathology aids in differentiating disease severity and predicting outcomes in acute cholangitis.