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Updated: Oct 31, 2025

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
Published on: June 18, 2018
[Reticular and Golgi glycosylation: Advances and associated diseases]
Sophie Groux-Degroote1, François Foulquier1, Sumeyye Cavdarli1
1Univ. Lille, CNRS, UMR 8576 - UGSF - Unité de glycobiologie structurale et fonctionnelle, Avenue Mendeleïev, 59655 Villeneuve-d'Ascq, France.
Abstract:
Glycosylation is one of the essential modifications of proteins and lipids. It is carried out mainly in the endoplasmic reticulum and Golgi apparatus, and requires a specific molecular machinery associating several hundreds of glycosyltransferases, glycosidases, transporters and regulating proteins. Modifications of glycosylation are found in numerous diseases, notably in cancers. All types of glycosylation can be affected and this leads to dysfunctions of cellular metabolism. In this review, we present the current knowledge on the regulation of glycosylation mechanisms and illustrate how the alteration of these regulatory mechanisms can lead to abnormal protein and lipid glycosylation, and take part in the development of cancers.
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