Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

'Are you even listening?' - EEG-based decoding of absolute auditory attention to natural speech.

Journal of neural engineering·2024

Same author

Neuronal tuning and population representations of shape and category in human visual cortex.

Nature communications·2024

Same author

Identifying temporal correlations between natural single-shot videos and EEG signals.

Journal of neural engineering·2024

Same author

What are we<i>really</i>decoding? Unveiling biases in EEG-based decoding of the spatial focus of auditory attention.

Journal of neural engineering·2024

Same author

Sensor selection and miniaturization limits for detection of interictal epileptiform discharges with wearable EEG.

Journal of neural engineering·2023

Same author

Objective evaluation of stimulation artefact removal techniques in the context of neural spike sorting.

Journal of neural engineering·2022

Same journal

Cortex-anchored sensor-space harmonics for event-related EEG.

Journal of neural engineering·2026

Same journal

Neural mechanisms of mixed speech and grasp representation in sensorimotor cortices.

Journal of neural engineering·2026

Same journal

Developing a binary communication protocol between biological neural networks using virtual white matter.

Journal of neural engineering·2026

Same journal

Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation.

Journal of neural engineering·2026

Same journal

A neural mass modelling framework for evaluating EEG source localisation of seizure activity.

Journal of neural engineering·2026

Same journal

Functional and effective connectivity methods from SEEG for characterizing epileptogenic networks in refractory epilepsy: a comprehensive review and future directions.

Journal of neural engineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 31, 2025

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

A data-driven spike sorting feature map for resolving spike overlap in the feature space.

J Wouters¹, F Kloosterman^2,3,4, A Bertrand¹

¹KU Leuven, Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics and Leuven., Leuven, Belgium.

Journal of Neural Engineering

|June 28, 2021

Summary

This summary is machine-generated.

This study introduces a novel method for neuronal spike sorting that resolves overlapping spikes directly in the feature space. This approach simplifies the pipeline and improves accuracy without needing spike templates.

Keywords:

feature extraction neural network overlapping spikes spike sorting

More Related Videos

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

Related Experiment Videos

Last Updated: Oct 31, 2025

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

Area of Science:

Computational Neuroscience
Signal Processing
Machine Learning

Background:

Spike sorting is crucial for analyzing neural activity but is challenged by overlapping spikes.
Current methods for spike overlap resolution often require complex post-processing.
This can lead to biased estimates and reduced sorting performance.

Purpose of the Study:

To develop a novel spike sorting method that resolves overlapping spikes directly within the feature space.
To simplify the overall spike sorting pipeline.
To improve the accuracy and efficiency of neuronal data analysis.

Main Methods:

Designed a domain-specific feature map using a neural network architecture.
Trained the network for simultaneous spike sorting and overlap resolution.
Utilized a data augmentation procedure based on biophysical simulations for training.

Main Results:

Demonstrated method's effectiveness on independent and realistic test data.
Showcased generalization to unseen data.
Achieved sorting performance comparable to state-of-the-art methods without template reliance.

Conclusions:

Resolving spike overlap in the feature space simplifies the spike sorting pipeline.
The proposed method forms concentrated clusters for overlapping spikes, avoiding template bias.
This approach offers a more robust and streamlined solution for analyzing extracellular neural recordings.