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Cissus quadrangularis L: A comprehensive multidisciplinary review.

Piyush S Bafna¹, Payal H Patil¹, Saurabh K Maru²

¹H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist-Dhule, 425 405, Maharashtra, India.

Journal of Ethnopharmacology

|June 28, 2021

Summary

Cissus quadrangularis, known as Hadjod, shows significant therapeutic potential with demonstrated analgesic, anti-inflammatory, and anti-osteoporotic activities. Further research is needed to explore its full medicinal capabilities and molecular mechanisms for chronic ailments.

Keywords:

Anti-osteoporotic Cissus quadrangularis Formulations Hadjod Patents Pharmacology

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Area of Science:

Ethnomedicine
Pharmacology
Phytochemistry

Background:

Cissus quadrangularis L. (Vitaceae family) is a traditional medicinal herb used for various ailments like malaria, fever, and epilepsy.
It is known by various local names, including Hadjod, and has extensive ethnomedicinal applications.

Purpose of the Study:

To systematically review the botany, traditional uses, phytochemistry, pharmacology, toxicology, and patents of Cissus quadrangularis.
To explore the future therapeutic and scientific potential of this herb.

Main Methods:

Literature search conducted across databases like PubMed, EMBASE, and Scopus.
Screening of 408 records, with 155 articles selected for comprehensive information extraction.
Plant taxonomy confirmed using "The Plant List" database.

Main Results:

Phytochemical analysis revealed flavonoids, triterpenoids, alkaloids, saponins, iridoids, stilbenes, vitamins, steroids, and glycosides.
Pharmacological studies demonstrated analgesic, anti-inflammatory, anticonvulsant, antimicrobial, anticancer, and anti-osteoporotic activities.
Toxicity studies indicated a high LD50 (>3000 mg/kg), suggesting safety; patents filed for its anti-osteoporotic properties.

Conclusions:

Extensive research exists, but gaps remain in understanding molecular mechanisms and structure-activity relationships.
Further investigation is warranted to elucidate synergistic/antagonistic effects of its components.
Cissus quadrangularis shows promise for managing various chronic ailments beyond its traditional uses.